Fetal Pulmonary Hypoplasia


First Edition

The human lung is a complex and highly specialized organ with over 40 differentiated cell types. Optimal lung function is determined prenatally and an in utero adverse event may interfere with the delicate lung development process and lead to variable degrees of pulmonary hypoplasia.

Fetal lung underdevelopment is a major concern for obstetricians and pediatricians since pulmonary hypoplasia (PH) may lead to severe respiratory distress immediately after birth and even to neonatal death or potential long-term morbidity. During a five year period, the author had the opportunity to conduct in experienced teams several studies on different fetal malformations that dealt with multiple aspects in the wide spectrum of PH: gastroschisis (GAS), giant omphalocele (GO), low obstructive uropathies (LUTO) and congenital diaphragmatic hernia (CDH). The thesis, which focuses on four papers published as first author, reviews important features of PH for a fetal medicine specialist. Three other publications as co-author are presented at the end of the manuscript as "additional contributions".


Paperback - In English 28.00 €

Specifications


Publisher
Presses universitaires de Louvain
Author
Jean-Marc Biard,
Collection
Hors collection (Presses universitaires de Louvain)
Language
English
BISAC Subject Heading
MED094000 MEDICAL / Pediatric Emergencies
Onix Audience Codes
06 Professional and scholarly
CLIL (Version 2013-2019)
3169 Spécialités médicales
Audience
Médecins spécialistes
Title First Published
01 April 2010
Type of Work
Thesis
Includes
Bibliography
Original Language
English

Paperback


Publication Date
01 April 2010
ISBN-13
9782874632051
Extent
Main content page count : 186
Legal Copyright Date
D/2010/9964/4
Code
82435
Dimensions
16 x 24 x 1.1 cm
Weight
306 grams
List Price
28.00 €
ONIX XML
Version 2.1, Version 3

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Contents


CHAPTER 1:
Introduction
1.1 Normal fetal lung development 11
1.2 Fetal lung growth regulation 16
1.3 Purpose of the thesis 18
1.4 Content of the thesis 19

CHAPTER 2:
Pulmonary Hypoplasia (PH)
2.1 Definition 21
2.2 Epidemiology 23
2.3 Factors adversely affecting lung growth leading to PH 24
2.3.1 Reduction in intrathoracic space 25
2.3.1.1 Congenital diaphragmatic hernia (CDH) 25
2.3.1.2 Congenital cystic adenomatoid malformation
(CPAM) 32
2.3.1.3 Bronchopulmonary sequestration (BPS) 37
2.3.1.4 Fetal pleural effusions 39
2.3.1.5 Skeletal disorders 41
2.3.2 Reduction in fetal breathing movements (FBM) 43
2.3.2.1 Anterior abdominal wall defects (AWD) 44
2.3.2.2 Reduction in amniotic and lung fluid volume 61

CHAPTER 3:
Prenatal management of pulmonary hypoplasia and potential
therapeutic approach
3.1 Pulmonary hypoplasia: prenatal diagnosis and evaluation 65
3.2 Pulmonary hypoplasia in lower obstructive uropathies
(LUTO) 69
3.3 Pulmonary hypoplasia in CDH 85
3.3.1 Role of left main bronchus occlusion
in the prenatal treatment of CDH 85

CHAPTER 4:
Summary, general discussion and perspectives 117
REFERENCES 125
ADDITIONAL CONTRIBUTIONS 143